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Coverage of recommended vaccines during pregnancy in Flanders, Belgium. Fairly good but can we do better?

Identifieur interne : 000011 ( Main/Exploration ); précédent : 000010; suivant : 000012

Coverage of recommended vaccines during pregnancy in Flanders, Belgium. Fairly good but can we do better?

Auteurs : Kirsten Maertens [Belgique] ; Tessa Braeckman [Belgique] ; Stéphanie Blaizot [Belgique] ; Heidi Theeten [Belgique] ; Mathieu Roelants [Belgique] ; Karel Hoppenbrouwers [Belgique] ; Elke Leuridan [Belgique] ; Pierre Van Damme [Belgique] ; Corinne Vandermeulen [Belgique]

Source :

RBID : pubmed:29627238

Descripteurs français

English descriptors

Abstract

BACKGROUND

In Flanders, Belgium, pertussis vaccination is recommended since 2013 and available free-of-charge in every pregnancy between 24 and 32 weeks of gestation. Influenza vaccination is recommended for more than 10 years with a co-payment system in the second or third trimester of pregnancy, when pregnancy coincides with the influenza season. This study aims to estimate the coverage of pertussis and influenza vaccination during pregnancy in 2016 and to determine predictors for missing vaccination.

METHODS

Postpartum women were visited at home for a vaccination coverage survey using an Expanded Program on Immunization (EPI)-based two-stage cluster sampling design. Predictors for missed vaccination were identified using a multiple logistic regression model.

RESULTS

Among 481 participating women, 69.3% were vaccinated against pertussis and 47.2% were vaccinated against influenza. Moreover, 65.3% of pertussis vaccine recipients and 96.9% of influenza vaccine recipients were vaccinated within the recommended gestational window. Surprisingly, among women who were completely informed (i.e. on disease-associated risks, maternal vaccination costs and recommendations), still 12.4% were unvaccinated against pertussis and 23.9% against influenza. In the final models, the only common predictor of missing maternal pertussis and influenza vaccination was multiparity. Significant predictors of maternal pertussis vaccination were family income (less likely if unknown or low (< €3000) than if moderate (€3001-€4000)) and hospital of delivery (less likely if >800 annual deliveries than <800). Significant predictors of maternal influenza vaccination, though with less straight-forward associations, were maternal ethnicity and educational level, involvement of a gynaecologist in pregnancy follow-up, and characteristics of the hospital of delivery.

CONCLUSION

In Flanders, more than two-third of pregnant women receives pertussis vaccination but less than half of them receives the influenza vaccine. Further improvement for both maternal vaccination programs can be achieved by targeting the underserved populations and diminishing vaccination hurdles.


DOI: 10.1016/j.vaccine.2018.03.033
PubMed: 29627238


Affiliations:


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<term>Immunization Programs</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Pertussis Vaccine (therapeutic use)</term>
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<term>Belgique</term>
<term>Enquêtes de santé</term>
<term>Facteurs socioéconomiques</term>
<term>Femelle</term>
<term>Femmes enceintes</term>
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<p>
<b>BACKGROUND</b>
</p>
<p>In Flanders, Belgium, pertussis vaccination is recommended since 2013 and available free-of-charge in every pregnancy between 24 and 32 weeks of gestation. Influenza vaccination is recommended for more than 10 years with a co-payment system in the second or third trimester of pregnancy, when pregnancy coincides with the influenza season. This study aims to estimate the coverage of pertussis and influenza vaccination during pregnancy in 2016 and to determine predictors for missing vaccination.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Postpartum women were visited at home for a vaccination coverage survey using an Expanded Program on Immunization (EPI)-based two-stage cluster sampling design. Predictors for missed vaccination were identified using a multiple logistic regression model.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Among 481 participating women, 69.3% were vaccinated against pertussis and 47.2% were vaccinated against influenza. Moreover, 65.3% of pertussis vaccine recipients and 96.9% of influenza vaccine recipients were vaccinated within the recommended gestational window. Surprisingly, among women who were completely informed (i.e. on disease-associated risks, maternal vaccination costs and recommendations), still 12.4% were unvaccinated against pertussis and 23.9% against influenza. In the final models, the only common predictor of missing maternal pertussis and influenza vaccination was multiparity. Significant predictors of maternal pertussis vaccination were family income (less likely if unknown or low (< €3000) than if moderate (€3001-€4000)) and hospital of delivery (less likely if >800 annual deliveries than <800). Significant predictors of maternal influenza vaccination, though with less straight-forward associations, were maternal ethnicity and educational level, involvement of a gynaecologist in pregnancy follow-up, and characteristics of the hospital of delivery.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>In Flanders, more than two-third of pregnant women receives pertussis vaccination but less than half of them receives the influenza vaccine. Further improvement for both maternal vaccination programs can be achieved by targeting the underserved populations and diminishing vaccination hurdles.</p>
</div>
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<Title>Vaccine</Title>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2018.03.033</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND">In Flanders, Belgium, pertussis vaccination is recommended since 2013 and available free-of-charge in every pregnancy between 24 and 32 weeks of gestation. Influenza vaccination is recommended for more than 10 years with a co-payment system in the second or third trimester of pregnancy, when pregnancy coincides with the influenza season. This study aims to estimate the coverage of pertussis and influenza vaccination during pregnancy in 2016 and to determine predictors for missing vaccination.</AbstractText>
<AbstractText Label="METHODS">Postpartum women were visited at home for a vaccination coverage survey using an Expanded Program on Immunization (EPI)-based two-stage cluster sampling design. Predictors for missed vaccination were identified using a multiple logistic regression model.</AbstractText>
<AbstractText Label="RESULTS">Among 481 participating women, 69.3% were vaccinated against pertussis and 47.2% were vaccinated against influenza. Moreover, 65.3% of pertussis vaccine recipients and 96.9% of influenza vaccine recipients were vaccinated within the recommended gestational window. Surprisingly, among women who were completely informed (i.e. on disease-associated risks, maternal vaccination costs and recommendations), still 12.4% were unvaccinated against pertussis and 23.9% against influenza. In the final models, the only common predictor of missing maternal pertussis and influenza vaccination was multiparity. Significant predictors of maternal pertussis vaccination were family income (less likely if unknown or low (< €3000) than if moderate (€3001-€4000)) and hospital of delivery (less likely if >800 annual deliveries than <800). Significant predictors of maternal influenza vaccination, though with less straight-forward associations, were maternal ethnicity and educational level, involvement of a gynaecologist in pregnancy follow-up, and characteristics of the hospital of delivery.</AbstractText>
<AbstractText Label="CONCLUSION">In Flanders, more than two-third of pregnant women receives pertussis vaccination but less than half of them receives the influenza vaccine. Further improvement for both maternal vaccination programs can be achieved by targeting the underserved populations and diminishing vaccination hurdles.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Maertens</LastName>
<ForeName>Kirsten</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Centre for the Evaluation of Vaccination, VAXINFECTIO, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. Electronic address: kirsten.maertens@uantwerp.be.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Braeckman</LastName>
<ForeName>Tessa</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Centre for the Evaluation of Vaccination, VAXINFECTIO, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Blaizot</LastName>
<ForeName>Stéphanie</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Centre for Health Economics Research and Modelling Infectious Diseases, VAXINFECTIO, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Theeten</LastName>
<ForeName>Heidi</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Centre for the Evaluation of Vaccination, VAXINFECTIO, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Roelants</LastName>
<ForeName>Mathieu</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Environment and Health, KU Leuven, Kapucijnenvoer 35 blok d, 3000 Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hoppenbrouwers</LastName>
<ForeName>Karel</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Environment and Health, KU Leuven, Kapucijnenvoer 35 blok d, 3000 Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Leuridan</LastName>
<ForeName>Elke</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Centre for the Evaluation of Vaccination, VAXINFECTIO, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Van Damme</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Centre for the Evaluation of Vaccination, VAXINFECTIO, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Vandermeulen</LastName>
<ForeName>Corinne</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Leuven University Vaccinology Center, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2018</Year>
<Month>04</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Netherlands</Country>
<MedlineTA>Vaccine</MedlineTA>
<NlmUniqueID>8406899</NlmUniqueID>
<ISSNLinking>0264-410X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010567">Pertussis Vaccine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001530" MajorTopicYN="N">Belgium</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006306" MajorTopicYN="N">Health Surveys</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D017589" MajorTopicYN="N">Immunization Programs</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D010567" MajorTopicYN="N">Pertussis Vaccine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D049590" MajorTopicYN="N">Postpartum Period</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D037841" MajorTopicYN="N">Pregnant Women</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000073887" MajorTopicYN="N">Vaccination Coverage</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="Y">Influenza</Keyword>
<Keyword MajorTopicYN="Y">Pregnancy</Keyword>
<Keyword MajorTopicYN="Y">Survey</Keyword>
<Keyword MajorTopicYN="Y">Tetanus-Diphtheria-Acellular Pertussis</Keyword>
<Keyword MajorTopicYN="Y">Vaccination coverage</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2017</Year>
<Month>10</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2018</Year>
<Month>03</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2018</Year>
<Month>03</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2018</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2018</Year>
<Month>12</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2018</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">29627238</ArticleId>
<ArticleId IdType="pii">S0264-410X(18)30378-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.vaccine.2018.03.033</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Belgique</li>
</country>
<region>
<li>Province d'Anvers</li>
<li>Province du Brabant flamand</li>
<li>Région flamande</li>
</region>
<settlement>
<li>Anvers</li>
<li>Louvain</li>
</settlement>
<orgName>
<li>Université d'Anvers</li>
</orgName>
</list>
<tree>
<country name="Belgique">
<region name="Région flamande">
<name sortKey="Maertens, Kirsten" sort="Maertens, Kirsten" uniqKey="Maertens K" first="Kirsten" last="Maertens">Kirsten Maertens</name>
</region>
<name sortKey="Blaizot, Stephanie" sort="Blaizot, Stephanie" uniqKey="Blaizot S" first="Stéphanie" last="Blaizot">Stéphanie Blaizot</name>
<name sortKey="Braeckman, Tessa" sort="Braeckman, Tessa" uniqKey="Braeckman T" first="Tessa" last="Braeckman">Tessa Braeckman</name>
<name sortKey="Hoppenbrouwers, Karel" sort="Hoppenbrouwers, Karel" uniqKey="Hoppenbrouwers K" first="Karel" last="Hoppenbrouwers">Karel Hoppenbrouwers</name>
<name sortKey="Leuridan, Elke" sort="Leuridan, Elke" uniqKey="Leuridan E" first="Elke" last="Leuridan">Elke Leuridan</name>
<name sortKey="Roelants, Mathieu" sort="Roelants, Mathieu" uniqKey="Roelants M" first="Mathieu" last="Roelants">Mathieu Roelants</name>
<name sortKey="Theeten, Heidi" sort="Theeten, Heidi" uniqKey="Theeten H" first="Heidi" last="Theeten">Heidi Theeten</name>
<name sortKey="Van Damme, Pierre" sort="Van Damme, Pierre" uniqKey="Van Damme P" first="Pierre" last="Van Damme">Pierre Van Damme</name>
<name sortKey="Vandermeulen, Corinne" sort="Vandermeulen, Corinne" uniqKey="Vandermeulen C" first="Corinne" last="Vandermeulen">Corinne Vandermeulen</name>
</country>
</tree>
</affiliations>
</record>

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